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Ideally, once platelet-based microvehicles bind to atherosclerotic sites, they would sharply switch to ultrasmall nanoparticles for deep plaque penetration and lesional macrophage intervention

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The others proteins identified as differentially expressed were related to heme synthesis (Biliverdin reductase A) and antioxidant enzymes (Peroxiredoxin 6, Glutathione S-transferase P) which may reflect an increase of free radical levels and consequent induction of antioxidant enzymes to protect against apoptosis 32

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